Detection of the Antiviral Drug Oseltamivir in Aquatic Environments
Identifieur interne : 001118 ( Main/Exploration ); précédent : 001117; suivant : 001119Detection of the Antiviral Drug Oseltamivir in Aquatic Environments
Auteurs : Hanna Söderström [Suède] ; Josef D. J Rhult [Suède] ; Björn Olsen [Suède] ; Richard H. Lindberg [Suède] ; Hiroaki Tanaka [Japon] ; Jerker Fick [Suède]Source :
- PLoS ONE [ 1932-6203 ] ; 2009.
Abstract
Oseltamivir (Tamiflu®) is the most important antiviral drug available and a cornerstone in the defence against a future influenza pandemic. Recent publications have shown that the active metabolite, oseltamivir carboxylate (OC), is not degraded in sewage treatment plants and is also persistent in aquatic environments. This implies that OC will be present in aquatic environments in areas where oseltamivir is prescribed to patients for therapeutic use. The country where oseltamivir is used most is Japan, where it is used to treat seasonal flu. We measured the levels of OC in water samples from the Yodo River system in the Kyoto and Osaka prefectures, Japan, taken before and during the flu-season 2007/8. No OC was detected before the flu-season but 2–58 ng L−1 was detected in the samples taken during the flu season. This study shows, for the first time, that low levels of oseltamivir can be found in the aquatic environment. Therefore the natural reservoir of influenza virus, dabbling ducks, is exposed to oseltamivir, which could promote the evolution of viral resistance.
Url:
DOI: 10.1371/journal.pone.0006064
PubMed: 19557131
PubMed Central: 2699036
Affiliations:
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J Rhult</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Section of Infectious Diseases, Department of Clinical Sciences, Uppsala University Hospital, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Section of Infectious Diseases, Department of Clinical Sciences, Uppsala University Hospital, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Olsen, Bjorn" sort="Olsen, Bjorn" uniqKey="Olsen B" first="Björn" last="Olsen">Björn Olsen</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Section of Infectious Diseases, Department of Clinical Sciences, Uppsala University Hospital, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Section of Infectious Diseases, Department of Clinical Sciences, Uppsala University Hospital, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Section for Zoonotic Ecology and Epidemiology, Kalmar University, Kalmar, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Section for Zoonotic Ecology and Epidemiology, Kalmar University, Kalmar</wicri:regionArea><wicri:noRegion>Kalmar</wicri:noRegion></affiliation></author><author><name sortKey="Lindberg, Richard H" sort="Lindberg, Richard H" uniqKey="Lindberg R" first="Richard H." last="Lindberg">Richard H. 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Recent publications have shown that the active metabolite, oseltamivir carboxylate (OC), is not degraded in sewage treatment plants and is also persistent in aquatic environments. This implies that OC will be present in aquatic environments in areas where oseltamivir is prescribed to patients for therapeutic use. The country where oseltamivir is used most is Japan, where it is used to treat seasonal flu. We measured the levels of OC in water samples from the Yodo River system in the Kyoto and Osaka prefectures, Japan, taken before and during the flu-season 2007/8. No OC was detected before the flu-season but 2–58 ng L<sup>−1</sup> was detected in the samples taken during the flu season. This study shows, for the first time, that low levels of oseltamivir can be found in the aquatic environment. Therefore the natural reservoir of influenza virus, dabbling ducks, is exposed to oseltamivir, which could promote the evolution of viral resistance.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Olsen, B" uniqKey="Olsen B">B Olsen</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="Wallensten, A" uniqKey="Wallensten A">A Wallensten</name></author><author><name sortKey="Waldenstrom, J" uniqKey="Waldenstrom J">J Waldenstrom</name></author><author><name sortKey="Osterhaus, Adme" uniqKey="Osterhaus A">ADME Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Gorman, Ot" uniqKey="Gorman O">OT Gorman</name></author><author><name sortKey="Chambers, 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Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singer, Ac" uniqKey="Singer A">AC Singer</name></author><author><name sortKey="Howard, Bm" uniqKey="Howard B">BM Howard</name></author><author><name sortKey="Johnson, Ac" uniqKey="Johnson A">AC Johnson</name></author><author><name sortKey="Knowles, Cj" uniqKey="Knowles C">CJ Knowles</name></author><author><name sortKey="Jackman, S" uniqKey="Jackman S">S Jackman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Monto, As" uniqKey="Monto A">AS Monto</name></author><author><name sortKey="Mckimm Breschkin, J" uniqKey="Mckimm Breschkin J">J McKimm-Breschkin</name></author><author><name sortKey="Macken, C" uniqKey="Macken C">C Macken</name></author><author><name sortKey="Hampson, Aw" uniqKey="Hampson A">AW Hampson</name></author><author><name sortKey="Hay, A" uniqKey="Hay A">A 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J Rhult</name><name sortKey="Lindberg, Richard H" sort="Lindberg, Richard H" uniqKey="Lindberg R" first="Richard H." last="Lindberg">Richard H. Lindberg</name><name sortKey="Olsen, Bjorn" sort="Olsen, Bjorn" uniqKey="Olsen B" first="Björn" last="Olsen">Björn Olsen</name><name sortKey="Olsen, Bjorn" sort="Olsen, Bjorn" uniqKey="Olsen B" first="Björn" last="Olsen">Björn Olsen</name></country><country name="Japon"><region name="Région du Kansai"><name sortKey="Tanaka, Hiroaki" sort="Tanaka, Hiroaki" uniqKey="Tanaka H" first="Hiroaki" last="Tanaka">Hiroaki Tanaka</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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